Neurocognitive Effects of Buprenorphine Among HIV+ and HIV-Opioid Users

Exclusion Criteria

• •Over age 60: Participants over the age of 60 will be excluded, as normal age-associated cognitive changes may confound neuropsychological (NP) assessment and diagnosis of HIV-related cognitive disorders.
• •Neurologic: History of head injury with loss of consciousness for greater than 12 hours; previous penetrating skull wounds; previous brain surgery; known seizure disorder, or any other non-HIV related CNS disorders that might affect neurocognitive functioning (e.g., previous cerebrovascular accident, Parkinson's disease, multiple sclerosis, brain tumor).
• •Medical: e.g. collagen vascular disorder (e.g. lupus), oxygen requiring chronic pulmonary disease,, or end stage renal disease requiring dialysis.
• •Psychiatric: Lifetime diagnosis of schizophrenia or bipolar disorder.
• •Less than 6 years of education.
• •Acute intoxication due to alcohol or other drugs, as assessed by research staff.
• •Use of buprenorphine in the past month, either prescribed or purchased on the street.