Vasopressin Deficiency in Hemorrhagic Shock

NCT01107314•The University of Texas Health Science Center at San Antonio

Summary

In this study we hope to delineate the typical vasoactive mediator response of trauma patients to shock. We plan to assess serum levels of vasopressin and also catecholamines, angiotensin, and cortisol during resuscitation of trauma patients to delineate high risk populations for vasopressin deficiency.

Detailed Description

This is a prospective observational study. The only research-driven procedure will be the removal of blood samples at designated time points(total blood removed 48 cc per patient). Hemodynamic, fluid infusion and agitation/pain data (RAMSEY Score) will prospectively be collected for research purposes. We will collect data from a convenience sample of patients (when research staff is available) over a one year period.

Eligibility

Age

18 - 98 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Patient is a male or female patient presumed to be at least 18 years of age;
•Patient has a reported or actual systolic blood pressure \< 90 mmHg within 1 hour of arrival to the Emergency Room;
•Patient has clinical evidence of acute traumatic injury;

Exclusion Criteria

•Patient is asystolic or requires CPR prior to arrival;
•Patient was transferred from an outside facility
•Patient known to be pregnant
•Patient known to be prisoner

Locations (1)

UTHSCSA

San Antonio, Texas, United States

Key Dates

Start Date

February 1, 2010

Primary Completion Date

April 30, 2011

Completion Date

April 30, 2011

Last Updated

January 17, 2018

Enrollment

ACTUAL participants

Conditions

Body Response to Trauma

Interventions

Phlebotomy

OTHER