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WITHDRAWN

Catheter Ablation for Atrial Fibrillation and Heart Failure

Pulmonary Vein Isolation for Rhythm Control in Patients With Atrial Fibrillation and Left Ventricular Dysfunction: A Pilot Study

NCT01082601•St. Luke's-Roosevelt Hospital Center

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Summary

To compare heart function, symptoms, exercise capacity and quality of life in patients with Congestive Heart Failure (CHF) and Atrial Fibrillation (AF)before and after catheter ablation. Hypothesis: Restoration and maintenance of sinus rhythm by catheter ablation, without the use of antiarrhythmic drugs, in AF and CHF improves heart failure status.

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Age 18 years to 80 years
•Clinical diagnosis of CHF based on symptoms (Shortness of breath, fatigue, peripheral edema)
•Systolic left ventricular dysfunction with ejection fraction 40% or less
•NYHA Class I, II or III heart failure
•Paroxysmal AF(2 or more episodes in one month) that terminate within 7 days:or persistent AF (more than 7 days or less than 7 days but terminated with pharmacologic or electrical cardioversion).
•Willing and able to sign informed consent

Exclusion Criteria

•Previous ablation
•Left atrial size greater than 60mm(parasternal view on transthoracic echocardiogram)
•AF episodes triggered by another uniform arrhythmia(e.g.atrial flutter or atrial tachycardia)
•Active alcohol or drug abuse, which may be causative of AF
•Severe valvular disease requiring surgical repair
•Myocardial infarction within 6 months of enrollment
•Abnormality that prevents catheter introduction
•Coronary surgical revascularization or other cardiac surgery within 6 months of enrollment
•Patients in whom heart transplant expected with 6 months
•AF deemed secondary to a transient or correctable cause (e.g.electrolyte imbalance ,trauma,recent surgery,,infection, toxic ingestion or endocrinopathy
+12 more criteria

Locations (2)

The Valley Hospital

Ridgewood, New Jersey, United States

St.Luke's-Roosevelt Hospital

New York, New York, United States

Key Dates

Start Date

April 1, 2010

Primary Completion Date

January 1, 2012

Completion Date

January 1, 2012

Last Updated

October 17, 2012

Conditions

Congestive Heart FailureAtrial FibrillationArrhythmia

Interventions

Pulmonary Vein Isolation (PVI)

PROCEDURE

The CONFORM Pivotal Trial

NCT05147792

Atrial FibrillationStroke

View study

RECRUITINGNA

Artificial Intelligence Mapping and Ablation of Non-Pulmonary Vein Electrical Drivers of AF Study

NCT06935591

Atrial Fibrillation (AF)

View study

RECRUITINGNA

The Fourth Left Atrial Appendage Occlusion Study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 17, 2012Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Catheter Ablation for Atrial Fibrillation and Heart Failure

Inclusion Criteria

Exclusion Criteria

The CONFORM Pivotal Trial

Artificial Intelligence Mapping and Ablation of Non-Pulmonary Vein Electrical Drivers of AF Study

The Fourth Left Atrial Appendage Occlusion Study

Medtronic Terminate AF Study

The CoAGulation Biomarkers and Atrial Fibrillation (COAG-AF) Pilot Study

cOncomitant Left Atrial aPpendage Closure and Pulsed Field ablaTION-Asia