Linagliptin Versus Placebo in Type 2 Diabetic Patients With Inadequate Glycaemic Control on Metformin in Combination With Pioglitazone

Exclusion Criteria

• •1. Uncontrolled hyperglycaemia during run in period
• •2. Myocardial infarction, stroke or transient ischaemic accident within 3 months prior to informed consent
• •3. Impaired hepatic function
• •4. Gastric by pass surgery
• •5. Treatment with roziglitazone, GLP 1 analogues, DPP-4 inhibitors or insulin within 3 months prior to informed consent
• •6. Treatment with anti-obesity drugs
• •7. Current treatment with systemic steroids at the time of informed consent or change in dosage of thyroid hormones within 6 weeks prior to informed consent
• •8. Premenopausal women who are nursing or pregnant or are of child-bearing potential and are not practicing an acceptable method of birth control or do not plan to continue using this method during the trial