A 6 Month Safety and Efficacy Study of Once Daily Ciclesonide Hydrofluoroalkane (HFA) in the Treatment of Perennial Allergic Rhinitis (PAR) in Subjects 12 Years and Older

Female subject who is pregnant or lactating.

History of physical findings of nasal pathology, including nasal polyps or other clinically significant respiratory tract malformations; recent nasal biopsy; nasal trauma; or nasal ulcers or perforations. Surgery and atrophic rhinitis or rhinitis medicamentosa are not permitted within the last 60 days prior to the Screening visit.

Subject is, in the investigator's judgement, having a seasonal exacerbation at the time of screening.

Participation in any investigational drug trial within the 30 days preceding the Screening visit or planned participation in another investigational drug trial at any time during this trial.

A known hypersensitivity to any corticosteroid or any of the excipients in the formulation of ciclesonide.

History of a respiratory infection or disorder \[including, but not limited to bronchitis, pneumonia, influenza, severe acute respiratory syndrome (SARS)\] within the 14 days preceding the Screening visit.

History of alcohol or drug abuse within 2 years preceding the Screening visit .

History of a positive test for HIV, hepatitis B or hepatitis C.

Active asthma requiring treatment with inhaled or systemic corticosteroids and/or routine use of beta agonists and any controller drugs (eg, theophylline, leukotriene antagonists, etc.); intermittent use (less than or equal to 3 uses per week) of inhaled short acting beta-agonists is acceptable. Use of short acting beta-agonists for exercise-induced bronchospasm will be allowed.

Expected use of any disallowed concomitant medications during the treatment period.

Initiation of immunotherapy during the study period or dose escalation during the study period. However, initiation of immunotherapy 90 days or more prior to the Screening Visit and use of a stable (maintenance) dose (30 days or more) may be considered for inclusion.

Previous participation in an intranasal ciclesonide HFA nasal aerosol study.

Non-vaccinated exposure to or active infection with, chickenpox or measles within the 21 days preceding the Screening Visit.

Initiation of pimecrolimus cream 1% or greater or tacrolimus ointment 0.03% or greater during the study period or planned dose escalation during the study period.

Study participation by clinical investigator site employees and/or their immediate relatives who reside in the same household.

Study participation by more than one subject from the same household.

Have any of the following conditions that are judged by the investigator to be clinically significant and/or affect the subject's ability to participate in the clinical trial:

* impaired hepatic function including alcohol related liver disease or cirrhosis

* history of ocular disturbances, eg, glaucoma or posterior subcapsular cataracts

* any systemic infection

* hematological, hepatic, renal, endocrine (except for controlled diabetes mellitus or postmenopausal symptoms or hypothyroidism)

* gastrointestinal disease

* malignancy (excluding basal cell carcinoma)

* current neuropsychological condition with or without drug therapy • Any condition that, in the judgment of the investigator, would preclude the subject from completing the protocol with capture of the assessments as written.

What this study is about