Age

18–64

Sex

ALL

Healthy volunteers

Not accepted

Diagnostic and Statistical Manual-IV diagnosis of schizophrenia (all subtypes), illness duration greater than three years
Auditory and visual acuity adequate to complete cognitive tests
Stable dose of antipsychotics for at least 2 weeks prior to entry
Good physical health determined by complete physical examination, laboratory tests, and EKG
Capacity and willingness to give written informed consent.

Inability to read or speak English
Documented disease of the central nervous system
History of intellectual impairment pre-dating onset of symptoms of psychosis (e.g. mental retardation)
Clinically significant or unstable cardiovascular, renal, hepatic, gastrointestinal, pulmonary or hematologic conditions;
HIV positive
Patients on antidepressants, including monoamine oxidase inhibitors
Uncontrolled hypertension
Pregnancy
Patients with a current diagnosis of substance dependence
Significant history of violence
History of an eating disorder
Ready for discharge within the following 8 weeks.

Modafinil Augmentation in Chronic Schizophrenia and Schizoaffective Disorder