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Detemir Energy Expenditure Study | Clinical Trials | Clareo Health

COMPLETEDPHASE4

Detemir Energy Expenditure Study

A 24-week, National, Single-centre, Open-labelled, Randomised, Parallel-group Trial Comparing Energy Expenditure With Insulin Detemir Versus NPH Insulin Using a Basal-bolus Regimen With Insulin Aspart as the Mealtime Insulin in Subjects With Type 2 Diabetes

NCT00788840•University of Surrey

View on ClinicalTrials.gov

Summary

This is a study designed to compare the effects of 2 long-acting insulins, detemir and insulatard, on energy expenditure,weight, fat composition, gut hormone profiles, glycaemic control and fat and muscle gene expression over a 6 month period.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Type 2 diabetes
•2. Treated with metformin
•3. Already on treatment with a long-acting or intermediate insulin.
•4. Over 18 years of age,
•5. HbA1c \> 7.0%
•6. BMI 27-40
•7. Able and willing to perform self-blood glucose monitoring.
•8. Able and willing to maintain consistent eating habits throughout the entire trial period.
•9. Able and willing to maintain consistent physical activity level during the entire trial period

Exclusion Criteria

•1. Patients on sulphonylureas or thiazolidinediones
•2. Proliferative retinopathy that has required acute treatment within the last six months.
•3. Impaired hepatic or renal functions.
•4. Cardiac problems.
•5. Uncontrolled hypertension (treated or untreated).
•6. Mental incapacity, unwillingness or a language barrier precluding adequate understanding or co-operation.

Locations (1)

Cedar Centre, Royal Surrey County Hospital

Guildford, Surrey, United Kingdom

Key Dates

Start Date

January 1, 2008

Primary Completion Date

August 1, 2009

Completion Date

August 1, 2009

Last Updated

May 31, 2023

Enrollment

ACTUAL participants

Conditions

Type 2 Diabetes MellitusObesity

Interventions

Insulatard

DRUG

Detemir

DRUG

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 31, 2023Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Detemir Energy Expenditure Study

Inclusion Criteria

Exclusion Criteria

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