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Colonography Versus Colonoscopy in High Risk Patient | Clinical Trials | Clareo Health

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Colonography Versus Colonoscopy in High Risk Patient

Acceptability and Effectiveness of Colonography Compared to Colonoscopy for the Detection of Advanced Adenomas in Patients at High Risk for Colorectal Cancer

NCT00748449•Assistance Publique - Hôpitaux de Paris

View on ClinicalTrials.gov

Summary

to evaluate the acceptability of CT-colonography compared to colonoscopy for the detection of advanced adenomas in subpopulations at high risk of colorectal.

Detailed Description

Secondary objective: to evaluate the medical and economic impact of the implementation of CT- colonography in this setting.Methodology: prospective multicenter randomized controlled trial with direct patient benefitN° of patients to be included: 600 Study follow-up :1 consultation and 3 phone contacts (M1, M6 and M12)Evaluation criteria:Main endpoint: acceptability of the colorectal cancer screening (% of enrolled patients having actually undergone the exploration)Secondary endpoints: - cost/effectiveness ratio of the 2 diagnostic tests with calculation of the economic and medical costs. - number of advanced adenoma detected in each group- number of CRC cases detected in each group

Eligibility

Age

18 - 80 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Surveillance of patients with a personal history of advanced adenoma or CRC:
•Informed consent obtained
•Age ≥ 18 and ≤ 80 years old
•History of advanced adenomatous polyps
•Or history of non metastatic CRC with curative surgery and without other treatment more than 2 years before enrollment.
•Previous medical examination
•Screening of patients with a Family history of CRC at high risk:
•Informed consent obtained
•Age ≥ 18 and ≤ 80 years old
•First degree family history of colorectal cancer diagnosed \<60yrs during the five previous years-Previous medical examination
+7 more criteria

Exclusion Criteria

•Personal histories
•Age \< 18 or \>80 years old
•history of non adenomatous polyps
•history of Metastatic CRC
•familial adenomatous polyposis, Peutz-Jeghers syndrome, hereditary non polyposis colorectal cancer (HNPCC), juvenile polyposis syndrome
•Familial history of familial adenomatous polyposis

Locations (1)

Cochin

Paris, France

Key Dates

Start Date

June 1, 2008

Primary Completion Date

December 1, 2009

Completion Date

December 1, 2010

Last Updated

March 6, 2026

Enrollment

ACTUAL participants

Conditions

Colorectal Cancer

Interventions

Colonoscopy

PROCEDURE

CT-colonography

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 6, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Colonography Versus Colonoscopy in High Risk Patient

Inclusion Criteria

Exclusion Criteria

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