Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Vigo
Age
50–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Male or female subjects ≥ 50 years of age.
Impaired fasting glucose (≥ 100 and \< 126 mg/dl) in the last available blood test prior (≤ 3 months) to randomization, or diagnosis of type 2 diabetes prior to randomization.
All subjects must have at randomization a conventional clinic systolic/diastolic BP \< 160/100 mmHg.
Informed consent to participate in the study prior to any study procedures.
You may not be if
Known or suspected contraindications, including history of allergy to ASA.
Uncontrolled essential hypertension of Grade 2-3, i.e., systolic BP ≥ 160 mmHg and/or diastolic BP ≥ 100 mmHg before randomization.
Evidence of a secondary form of hypertension, to include coarctation of the aorta, hyperaldosteronism, renal artery stenosis, or pheochromocytoma.
Known Keith-Wagener grade III or IV hypertensive retinopathy.
History of hypertensive encephalopathy, cerebrovascular event, transient ischemic cerebral attack, or myocardial infarction prior to randomization.
Type 1 diabetes mellitus.
History of heart failure.
Second or third degree heart block without a pacemaker.
Concomitant unstable angina pectoris.
Concomitant potentially life threatening arrhythmia or symptomatic arrhythmia.
Clinically significant valvular heart disease.
Evidence of hepatic disease as determined by one of the following: ALT or AST values \> 2 x UNL known before randomization, a history of hepatic encephalopathy, history of esophageal varices, or history of portocaval shunt.
Diagnosis of chronic kidney disease prior to randomization.
History of malignancy including leukemia and lymphoma (but not basal cell skin cancer), or any other severe, life-threatening disease within the past five years.
Any previous history of a systemic autoimmune disease.
History of drug or alcohol abuse within the last two years.
Use of any disallowed concomitant medication.
Inability to communicate and comply with all study requirements.
Persons directly involved in the execution of this protocol.
