Targeting Inflammation Using Salsalate in CardioVascular Disease

Exclusion Criteria

• •1. Unstable angina (increase in frequency or severity of anginal episodes or development of chest pain at rest)
• •2. significant obstructive disease (≥ 70%) in left main coronary artery, ostial LAD or three-vessel disease by MDCTA
• •3. Significant heart failure (NYHA class III and IV)
• •4. Current atrial fibrillation or Wolf-Parkinson-White (WPW) syndrome
• •5. Allergy to beta-blocker in subjects with resting heart rate \> 65 bpm
• •6. Systolic blood pressure \> 160 mm Hg
• •7. Diastolic BP \> 100 mm Hg
• •8. Persons with allergies to contrast material
• •9. History of asthma if unable to tolerate beta blocker
• •10. Allergy to iodinated contrast material or shellfish
• •11. Allergy to nitroglycerin
• •12. BMI \> 35 kg/m2 if female and \> 40 kg/m2 if male
• •13. Body weight \> 350 lbs
• •14. Use of drugs for weight loss \[e.g. Xenical (orlistat), Meridia (sibutramine), Acutrim (phenylpropanolamine) or similar over-the counter medications\] within three months of screening
• •15. Surgery within 30 days of screening
• •16. History of acquired immune deficiency syndrome or human immunodeficiency virus (HIV)
• •17. Poor mental function or history of dementia/ Alzheimer's Disease or on medications used for treatment of dementia \[e.g. Tacrine (Cognex), Rivastigmine (Exelon), Galantamine (Razadyne, Reminyl), Donepezil (Aricept), Memantine (Namenda)\] or any other reason to expect patient difficulty in complying with the requirements of the study
• •18. Medicine for erectile dysfunction within 72 hours prior to MDCTA
• •19. History of significant chronic rheumatologic or other chronic inflammatory disease (including foot ulcers)
• •20. Prior hemorrhagic stroke
• •21. persons with known aspirin allergy
• •22. Use of continuous oral corticosteroid treatment (more than 2 weeks), or patients requiring corticosteroids within 3 months
• •23. Anti-diabetic medication including thiazolidinedione (pioglitazone or rosiglitazone), or insulin or Extendin-4 (Byetta)
• •24. History of peptic ulcer or gastritis within 5 years
• •25. Positive stool guaiac
• •26. Hemoglobin 2 standard deviations below normal
• •27. Low platelet count (2 standard deviations below normal)
• •28. Known bleeding disorder
• •29. Coumadin (warfarin compounds)
• •30. History of type 1 diabetes and/or history of ketoacidosis
• •31. Daily use of NSAIDS (including salsalate) for arthritis
• •32. History of malignancy, except subjects who have been disease-free for greater than 5 years, or whose only malignancy has been basal or squamous cell skin carcinoma
• •33. History of drug or alcohol abuse, or current weekly alcohol consumption \>14 units/week (1 unit = 1 beer, 1 glass of wine, 1 mixed cocktail containing 1 ounce of alcohol)
• •34. Use of probenecid (Benemid, Probalan), sulfinpyrazone (Anturane) or other uricosuric agents
• •35. Chronic tinnitus.