Opioid-induced Bowel Dysfunction: Long-Term Assessment of Lubiprostone

Exclusion Criteria

• •Has newly diagnosed impaired renal function identified at the Screening Visit \[i.e., serum creatinine concentration \> 1.8 milligrams per deciliter (mg/dL)\]
• •Has experienced an unexplained and/or clinically significant weight loss defined as \> 5% within 90 days prior to Screening Visit.
• •Has plans to participate in another trial with an investigational drug or device during the course of the extension study