Modafinil Augmentation Therapy for Excessive Daytime Sleepiness and Negative Symptoms in Patients With Schizophrenia

Inclusion Criteria

• •Subjects must be able to communicate and give voluntary informed consent
• •Subjects must be of the male gender
• •Between the ages of 18 to 65 years.
• •A diagnosis of Schizophrenia or Schizoaffective disorder as determined by DSM-IV criteria.
• •Not conservatorized
• •A negative symptom score on the PANSS of \>= 20 and an MMSE score of \>24
• •No clinical evidence of a current unstable medical illness
• •No current clinical evidence or past history of cerebral neurological impairment (including strokes, tumors or trauma leading to loss of consciousness)
• •No history of drug or alcohol dependence in the past 2 years
• •No evidence of drug or alcohol abuse in the past year, as determined by the DSM-IV criteria.
• •No diagnosis of Narcolepsy as determined by DSM-IV criteria
• •Must have an approved contact person for the duration of the study
• •May be on a stable dose of SSRI for depressive symptoms
• •No history of aggression
• •No uncontrolled hypertension, as defined below (subjects cannot have any of the following):
• •1. a new diagnosis of hypertension, or
• •2. a change in antihypertensive medications in the past 30 days, or
• •3. acute hypertension (systolic\>160mmHg, diastolic\>100mmHg)
• •Maybe on a stable dose of a benzodiazepine
• •The following medications will not be allowed during the study- methylphenidate, amphetamines, pemoline, zolpidem, MAO inhibitors, anticoagulant, TCA's, or barbiturates.
• •Be on a stable does of an atypical neuroleptic
• •May be on a stable does of an anticonvulsant for mood stabilization