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Endorphins are naturally occurring narcotic substances that are released when individuals perform exercise. The hypothesis of the study is that endorphins reduce the severity of breathlessness during exercise in patients with chronic obstructive pulmonary disease (COPD). The initial five visits include familiarization and validation of a computerized system for patients to report dyspnea and leg discomfort continuously during exercise testing. At Visits 6 and 7 blood is drawn to measure serum endorphin levels pre-exercise, end exercise, and 30 minutes after exercise. Normal saline or naloxone is given intravenously 5 minutes prior to exercise in a double-blinded design. The primary outcome is the slope of oxygen consumption - dyspnea.
Age
50 - 90 years
Sex
ALL
Healthy Volunteers
No
Dartmouth-Hitchcock Medical Center
Lebanon, New Hampshire, United States
Start Date
September 1, 2005
Completion Date
May 1, 2007
Last Updated
November 2, 2007
17
ACTUAL participants
naloxone versus placebo
DRUG
intravenous injection of normal saline or naloxone
DRUG
Lead Sponsor
Dartmouth-Hitchcock Medical Center
NCT07477600
NCT05878769
NCT06717659
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