Topotecan Plus Cisplatin Versus Etoposide Plus Cisplatin In 1st Line Extensive Disease Small Cell Lung Cancer

Exclusion Criteria

• •Extensive disease treatable with radiotherapy.
• •Past or current history of other malignant disease.
• •Prior chemotherapy.
• •Pregnancy, lactating or lack of effective contraception.
• •Concurrent severe medical problems other than small cell lung cancer.
• •Patients with central nervous system metastases receiving more than 12 mg /day dexamethasone or equivalent to control symptoms.