Loading clinical trials...

Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy | Clinical Trials | Clareo Health

COMPLETEDPHASE2

Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy

A Randomized, Parallel-Group, Double-Blind, Single-Dose Study Evaluating the Efficacy and Safety of Intravenous Lornoxicam (8 mg and 16 mg) Compared to Intravenous Placebo and Ketorolac 30 mg in Management of Acute Postoperative Pain Following Orthopedic Surgery (Bunionectomy).

NCT00293631•POZEN

View on ClinicalTrials.gov

Summary

To determine whether a single dose of intravenous lornoxicam is superior to intravenous placebo for management of post-operative pain in patients who have surgical removal of a bunion on the lower extremity. One-fourth of patients in this study will receive a single dose of intravenous ketorolac for management of pain and one-fourth of patients in this study will receive a single dose of an intravenous placebo.

Eligibility

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Subjects who are scheduled for a primary unilateral first metatarsal bunionectomy under local anesthetic.
•Subjects have no contraindications to this surgery and have no allergies to the study medications or similar medications.
•Subjects are in generally good health with no uncontrolled chronic illnesses or diseases.

Exclusion Criteria

•Subjects who are pregnant.
•Subjects who have significant obesity.
•Subjects with medically significant heart, liver, kidney, lung or endocrine disease.
•Subjects with active viral disease, i.e. hepatitis, HIV.

Locations (1)

Advanced Clinical Research Institute

Anaheim, California, United States

Key Dates

Start Date

November 1, 2005

Primary Completion Date

March 1, 2006

Completion Date

March 1, 2006

Last Updated

December 3, 2012

Enrollment

100

Estimated participants

Conditions

BunionectomyOrthopedic Surgery

Interventions

Lornoxicam 8 mg

DRUG

Lornoxicam 16 mg

DRUG

Ketorolac 30 mg

DRUG

Placebo

DRUG

Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery

NCT06995690

Post-spinal HypotensionOrthopedic Surgery+1 more

View study

RECRUITINGNA

Intermittent Fasting Versus Carbohydrate Drinks Before Surgery

NCT05760339

Perioperative CareIntermittent Fasting+4 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: December 3, 2012Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Study of Lornoxicam or Ketorolac or Placebo for Post-Operative Pain After Bunionectomy

Inclusion Criteria

Exclusion Criteria

Ketamine for Preventing Post-Spinal Hypotension in Orthopedic Surgery

Intermittent Fasting Versus Carbohydrate Drinks Before Surgery

Intravenous Dexmedetomidine Versus Midazolam in Preventing Shivering in Trauma Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia

Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients

Dexmedetomidine Supplemented Intravenous Analgesia in Elderly After Orthopedic Surgery

New Methods to Detect a Decrease in Heart Function