Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome

Exclusion Criteria

• •1. Patients taking greater than 81mg aspirin daily.
• •2. Patients taking anti-platelet drugs such as clopidogrel or non-steroidal anti-inflammatory drugs (NSAIDs) or anticoagulant drugs such as warfarin, during the last two weeks.
• •3. Patients taking any of the following medications for less than 3 months, or who plan to take them for the first time during the next 3 months: ACE-inhibitors, angiotensin receptor blockers, calcium channel blockers, or statins.
• •4. Patients who are currently cigarette smokers.
• •5. Women patients who are pregnant, planning to become pregnant, nursing a child, or taking hormone replacement therapy.
• •6. Patients with any coagulation, bleeding or blood disorders.
• •7. Patients who are sensitive or allergic to aspirin.
• •8. Patients with documented history of any gastrointestinal disorders, including bleeding ulcers.
• •9. Patients with any evidence of cancer or history of significant cardiovascular disease (including heart attack, stroke or drop attacks termed transient ischemic attacks (TIAs), or blockages of the arteries in the legs termed peripheral arterial disease (PAD)), kidney, liver, lung, blood, or brain disorders.
• •10. Patients with asthma, rhinitis, or nasal polyps.
• •11. Patients with any abnormal laboratory value or physical finding that, in the view of the responsible clinician, may interfere with interpretation of the study results, be indicative of an underlying disease state, or compromise the safety.
• •12. Patients with Class IV heart failure.
• •13. Patients with severe aortic insufficiency, or aortic regurgitation.
• •14. Patients with hearing loss or tinnitus.
• •15. Patients with tremors which cause them not to be able to remain motionless for approximately 30 seconds.