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A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine | Clinical Trials | Clareo Health

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A Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine

An Open-Label Study of Topiramate in Pediatric Subjects With Basilar/Hemiplegic Migraine

NCT00158002•Monarch Medical Research

Summary

The objective of this study is to assess the long-term safety and effectiveness of topiramate in the prevention of basilar and hemiplegic migraine in children and adolescents.

Detailed Description

This is a single-center, open-label study consisting of 3 phases: Blinded Transition Phase, Open-Label Maintenance Phase, and Taper/Exit Phase. Subjects who have either succesfully completed the CAPSS-271 protocol or who discontinued the CAPSS-271 study due to lack of effectiveness after completing at least 2 weeks of maintenance treatment will be eligible to enroll.

Eligibility

Age

6 - 18 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Must have either completed the Double-Blind Phase of CAPSS-271 or discontinued the Double-Blind Phase of CAPSS-271 due to lack of efficacy after a minimum of 2 weeks of maintenance treatment.
•Female subjects must be premenarchal, surgically sterile (hysterectomy, tubal ligation or otherwise incapable of pregnancy); or practicing an effective method of birth control (e.g., intrauterine device, double-barrier method, male partner sterilization) at study entry and throughout the study; or hormonal contraceptives for at least a 3-month period prior to the start of the study and throughout the study, or be practicing abstinence and agree to continue abstinence or to use an acceptable method of contraception (as listed above) should sexual activity commence. In addition, female subjects of childbearing potential must have a negative urine pregnancy test at Open-Label Visit 1 (Day 1).
•Must be able to read and comprehend written instructions and be willing to complete all headache records and questionnaires as required by the protocol.
•After full explanation of the study, subjects, or their parent/legally authorized representative(s), must demonstrate their willingness to participate by signing an informed consent form. If applicable, pediatric subjects capable of giving assent must sign the assent form.

Exclusion Criteria

•Subjects who have developed a more painful condition than their headache pain.
•Subjects taking any of the prohibited concomitant medications (See Concomitant Medications section).
•Subjects who are pregnant.
•Subjects with liver function tests ³ 2 times the upper limit of the normal range.
•In the investigator's opinion, subjects with poor compliance during the CAPSS-271 study

Locations (1)

Monarch Medical Research - Child and Adolescent Neurology

Norfolk, Virginia, United States

Key Dates

Start Date

February 1, 2004

Completion Date

August 1, 2006

Last Updated

April 5, 2007

Enrollment

Estimated participants

Conditions

Basilar Migraine

Interventions

Topiramate

DRUG