Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis

Effect of Intravenous Ceftriaxone and Oral Doxycycline for Lyme Neuroborreliosis. A Randomized Double-blind Comparison

NCT00138801•Sorlandet Hospital HF

Summary

The aim of this study is to compare parenteral ceftriaxone and oral doxycycline in the treatment of neuroborreliosis in a randomized controlled trial.

Eligibility

Age

18 - 100 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Neurological symptoms and/or findings consistent with neuroborreliosis and at least one of the following fulfilled:
•* Intrathecal production of borrelia antibodies;
•* White cell count in cerebrospinal fluid (CSF) \> 5/mm3;
•* Significant rise in borrelia antibodies in two serum samples collected from a patient with at least 3 weeks interval;
•* Verified acrodermatitis chronica atrophicans.

Exclusion Criteria

•Allergy to the contents in the medication, or earlier type I reaction to penicillin.
•Treatment with cephalosporins, penicillin or tetracyclins during the last 14 days
•Pregnancy or breastfeeding
•Age \< 18 years

Locations (1)

Sørlandet Sykehus HF

Kristiansand, Vest-Agder, Norway

Key Dates

Start Date

March 1, 2004

Primary Completion Date

March 1, 2008

Completion Date

December 1, 2008

Last Updated

May 6, 2023

Enrollment

120

ACTUAL participants

Conditions

Lyme Neuroborreliosis

Interventions

Ceftriaxone

DRUG

Doxycycline

DRUG