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Double Blinded Randomised Trial Comparing Metformin Versus Placebo in NASH Patients Receiving Bariatric Surgery for Obesity
This is a comparison of metformin versus placebo in NASH patients receiving bariatric surgery for obesity.
In patients receiving bariatric surgery, a preoperative liver biopsy will confirm the presence of NASH. Those patients with NASH (histologically defined according the Brunt's criteria) will be randomized to receive metformin (2 times 850 mg orally daily) or placebo for a time period of 1 year. A control liver biopsy will be performed after one year.
Age
All ages
Sex
ALL
Healthy Volunteers
No
University Hospital Ghent
Ghent, Belgium
Start Date
June 1, 2005
Primary Completion Date
March 31, 2006
Completion Date
March 31, 2006
Last Updated
December 8, 2022
65
ACTUAL participants
Metformin
DRUG
Lead Sponsor
University Hospital, Ghent
Collaborators
NCT01143454
NCT07472881
Data Source & Attribution
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