A Notch Signalling Pathway Inhibitor for Patients With Advanced Breast Cancer (0752-014)

Inclusion Criteria

• •Women or men greater than or equal to 18 years of age
• •ECOG status less than or equal to 2 (a measurement to determine your ability to perform daily activities)
• •In Parts I, III, and IV, patient must have a histologically confirmed, metastatic or locally advanced solid tumor that has failed to respond to standard therapy, progressed despite standard therapy, or for which standard therapy does not exist. There is no limit on the number of prior treatment regimens
• •In Part II, only breast cancer patients are eligible
• •In Part V, only patients with Numb negative breast cancer (i.e., tumor shows Numb immunoreactivity in less than 10% of the neoplastic cells assessed) are eligible
• •Patient has recovered from and is at least 2 weeks from previous antineoplastic therapy, including chemotherapy, biological therapy (including Herceptin), hormonal therapy, radiotherapy, or surgery