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OBJECTIVES: I. Determine the response rate and response duration to rituximab in patients with immune thrombocytopenic purpura. II. Evaluate the toxicity associated with this treatment regimen in these patients. III. Evaluate the alteration in antiplatelet antibody with this treatment regimen in these patients.
PROTOCOL OUTLINE: Patients receive rituximab IV on days 1, 8, 15, and 22. Patients who achieve a clinical response lasting over 4 months may receive a second course of rituximab. Patients are followed at 5, 6, 8, and 12 weeks, and then at 6 and 9 months.
Age
18 - No limit years
Sex
ALL
Healthy Volunteers
No
University of Alabama Comprehensive Cancer Center
Birmingham, Alabama, United States
Start Date
December 1, 2000
Primary Completion Date
August 1, 2007
Last Updated
September 9, 2008
20
Estimated participants
rituximab
DRUG
Lead Sponsor
University of Alabama at Birmingham
NCT03010202
NCT00547066
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT02334813