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Browse 40,629 clinical trials for rheumatoid arthritis. Find studies that match your criteria and connect with research centers.
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NCT07098598
Staging pancreatic cancer (PC) presents a clinical challenge. Triphasic whole body CT is the primary imaging method in diagnosing, staging and during follow up. Conventional PET/CT with 18F-labelled fluorodeoxyglucose (18F-FDG) has its limitations and therefore has a secondary role in imaging pancreatic cancer patients. These conventional imaging methods are good in detecting primary tumors and distant metastasis but poor in detecting local lymph node metastasis. A new PET tracer, fibroblast activation protein inhibitor (FAPI), targets FAP, a protein overexpressed in cancer-associated fibroblasts. It presents a potential new PET imagining tool. The objective of this prospective diagnostic study is to evaluate the diagnostic efficacy of 18F-FAPI-74 PET/CT in patients with PC. The aim is to evaluate the sensitivity and specificity of 18F-FAPI-74 in detection of local lymph node metastasis and distant metastasis in patient level in patients with PC in primary staging and when suspected recurrence. 100 patients with PC are enrolled on whom PET/CT studies are performed with the novel 18F-FAPI-74 tracer. The data will be collected between 2024-2026.
NCT07084337
This study aimed to evaluate the effects of an eight-week Bodypump® group training program on resting blood pressure and physical fitness in sedentary older adults with hypertension. Bodypump is a choreographed resistance exercise class performed in groups, guided by certified instructors, and accompanied by music. It uses light weights and high repetitions, making it accessible and engaging for older individuals. Thirty-two participants aged 55 and older with a medical diagnosis of hypertension were randomly assigned to either an intervention group (Bodypump classes, 3 times per week for 8 weeks) or a control group that maintained their usual sedentary behavior. The main outcome was resting blood pressure (systolic and diastolic). Secondary outcomes included measures of functional fitness assessed using the Senior Fitness Test (SFT) battery: lower and upper body strength, aerobic endurance, agility, and balance. Results showed a significant reduction in systolic and diastolic blood pressure in the Bodypump group compared to the control group. Participants also experienced significant improvements in physical performance measures. This study suggests that structured group-based resistance training programs such as Bodypump are an effective non-pharmacological intervention for improving cardiovascular health and functional fitness in older adults with hypertension.