Heart Disease Clinical Trials in Pittsburgh

Showing 301-320 of 455 trials

Personalized Risk Evaluation and Diagnosis (Using Corus CAD or ASGES) in the Coronary Tree

NCT00500617

The PREDICT study is to develop and validate a diagnostic blood ASGES (age, sex, gene expression score) or Corus CAD for atherosclerotic coronary artery disease (CAD). The Corus CAD (Age/Sex/Gene Expression score - ASGES) will use quantitative real-time PCR (RT-PCR) to quantify the expression of multiple genes from circulating peripheral blood cells to assess the presence of clinically significant CAD in a patient.

Coronary Artery DiseaseAngina PectorisChest Pain+5 more

CardioDx4,350 participantsStarted Jul 2007

Anchorage, Alaska, United States • Beverly Hills, California, United States • La Jolla, California, United States +7 more locations

COMPLETEDPhase 2< 1 mile

Oral Nitrite for Older Heart Failure Patients

NCT02457260

Studies have demonstrated nitrite therapy increases adenosine triphosphate (ATP) synthesis in skeletal muscle mitochondria concomitant with reduced whole-body oxygen cost during steady state exercise. Our own work has demonstrated safety and efficacy of an FDA investigational new drug (IND) approved sodium nitrite (10 milligram \[mg\]) capsule, and its utility to upregulate the sirtuin 3 adenosine monophosphate protein kinase (SIRT3-AMP) pathway of skeletal muscle of younger heart failure (HF) patients. It now seems exceptionally logical and opportune to apply these insights to older HF patients and to delineate mechanisms of disease and aging that respond to nitrite therapy.

Heart Failure

Gladwin, Mark, MD21 participantsStarted Jan 2016

Pittsburgh, Pennsylvania, United States

Personalized Risk Evaluation and Diagnosis (Using Corus CAD or ASGES) in the Coronary Tree

Oral Nitrite for Older Heart Failure Patients

Heart Disease Trials in Other Cities

Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable CAD in Post MI Patients

Pexelizumab in Patients Undergoing Coronary Artery Bypass Grafting With Cardiopulmonary Bypass (PRIMO-CABG II)

Registry of Non-primary Angioplasty at Hospitals Without Surgery On-site

CANVAS - CANagliflozin cardioVascular Assessment Study

IMPROVE HF: Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting

Subcutaneous Furosemide in Acute Decompensated Heart Failure: The SUBQ-HF Study

An Assessment of the Glider Balloon in Complex Lesions

Cardiovascular Improvements With MV ASV Therapy in Heart Failure

Vascular Inflammation in Psoriasis - Extension Study

Combined Non-invasive Coronary Angiography and Myocardial Perfusion Imaging Using 320 Detector Computed Tomography

Prospective Multicenter Registry On RadiaTion Dose Estimates Of Cardiac CT AngIOgraphy IN Daily Practice in 2017

AngioDefender Versus Brachial Artery Ultrasound Imaging

Pharmacodynamic Evaluation of Switching From Ticagrelor to Prasugrel in Subjects With Stable Coronary Artery Disease

Global Non-interventional Heart Failure Disease Registry

The BOSS Study: An Acute Evaluation of Anatomical and Geometric Changes Using the Bladder on a Stick System (BOSS)

Combination Therapy Compared With Single-Drug Therapy in Patients With Cardiac Diseases

Pharmacist-led Group Medical Visits to Help With Diabetes Management

Gadobutrol/Gadavist-enhanced Cardiac Magnetic Resonance Imaging (CMRI) to Detect Coronary Artery Disease (CAD)

Other Conditions in Pittsburgh